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Subjects with cardiovascular disease ( n = 14) had lower heart rate and cardiovascular double product and higher VD/Vt at peak exercise.

Results: In comparison with subjects without disease, subjects with pulmonary disease ( n = 31) had higher VE/V′CO 2 slope, higher VD/Vt, and lower ventilatory reserve.

Objectives: We hypothesized that increased physiological dead space ventilation (VD/Vt) is a marker for mild pulmonary or cardiovascular disease in patients with exertional dyspnea.ĭesign: We used receiver operating characteristic analysis to determine the performance of individual CPET parameters for identifying subjects with either mild pulmonary or cardiovascular disease, among 77 subjects with mild-to-moderate exertional dyspnea (modified Medical Research Council scale 1–2). Background: The characteristics of cardiopulmonary exercise testing (CPET)-derived parameters for the differential diagnosis of exertional dyspnea are not well known.